CHARACTERIZATION OF PF-6142, A NOVEL, NON-CATECHOLAMINE DOPAMINE RECEPTOR D1 AGONIST, IN MURINE AND NONHUMAN PRIMATE MODELS OF DOPAMINERGIC ACTIVATION

Selective activation of dopamine D1 receptors remains a promising pro-cognitive therapeutic strategy awaiting robust clinical investigation.PF-6142 is a key example from a recently disclosed novel series of non-catechol agonists and partial agonists of the dopamine D1/5 receptors (D1R) that exhibit pharmacokinetic (PK) properties suitable for oral

The article reveals the essence and features of the political debate in Sweden about the possible entry into NATO.The positions of party-electoral blocs are explained, arguments in favor of this or that decision are presented.The problem has become particularly acute on the eve of parliamentary elections in September 2018.The Sheds approximate equa

Legal language is hallmarked by a pedantic and user-unfriendly jargon whose constructs are all but intuitive, not to mention the legal system specificity which makes it unique in every country.Second language (L2) learners or scholars, hence, may find it difficult to understand the language of the law; whereas translators may consider legal lexical

In the presence of a continually changing sensory environment, maintaining stable but flexible awareness is paramount, and requires continual organization of information.Determining which stimulus features belong together, and which are separate is therefore one of the primary tasks of the sensory systems.Unknown is whether there is a global or sen